Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques

Genesis and growth of extracellular vesicle-derived microcalcification in atherosclerotic plaques

Clinical evidence links arterial calcification and cardiovascular risk. Finite-element modelling of the stress distribution within atherosclerotic plaques has suggested that subcellular microcalcifications in the fibrous cap may promote material failure of the plaque, but that large calcifications can stabilize it. Yet the physicochemical mechanisms underlying such mineral formation and growth ...

An Alternative Novel Mechanism for Microcalcification in Atherosclerotic Plaques

Macrophage-derived matrix vesicles: an alternative novel mechanism for microcalcification in atherosclerotic plaques.

RATIONALE We previously showed that early calcification of atherosclerotic plaques associates with macrophage accumulation. Chronic renal disease and mineral imbalance accelerate calcification and the subsequent release of matrix vesicles (MVs), precursors of microcalcification. OBJECTIVE We tested the hypothesis that macrophage-derived MVs contribute directly to microcalcification. METHODS...

Effect of Helicobacter pylori DNA in human atherosclerotic plaques

Introduction: A number of studies have demonstrated that infectious mico organisms like helicobacter pylori may play a role in the process of atherosclerosis. We, here, aimed to investigate the effect of Helicobacter pylori DNA in atherosclerotic plaques in patients with coronary artery disease. Methods: In a cross-sectional study, 85 patients undergoing coronary artery bypass graft (CAB...

Prevalence of Atherosclerotic Plaques in Autopsy Cases with Noncardiac Death

  Background and Objective: Ischemic heart disease (IHD) following atherosclerosis is the most common cause of cardiac deaths world wide. We aimed to investigate the pathologic features of atherosclerosis in non cardiac death cases to have an estimate of atherosclerosis prevalence in Mashad (North east of Iran). Patients and Methods : This descriptive (cross sectional) study was done, during ...